SMALL MOLECULES

Chemical Entities < 2 kD

DAISOGEL spherical silica gels were launched in 1992. At that time, the most common active pharmaceutical ingredients were traditional small molecule therapeutics. These products were the first applications for analysis and preparative purification using DAISOGEL.

Chemical entities such as paclitaxel for cancer treatment, beta blockers for hypertension, and statins for hypercholesterolemia were some of the top-selling pharmaceuticals in the 1990s. These entities are usually chemically synthesized and have a molecular weight of less than 2 kD – hence the term “small molecule.”

Scores of small molecules remain important treatment options today, especially as a multitude of competitively-priced generic options are available.

silica gels for purification of small molecules

Typical Applications

Examples of small molecules purified with DAISOGEL products

Alkaloids

Pyridine Derivatives

Organic Acids

Steroids

Beta Blockers

A Variety of Phases

Hydrophobic small molecules are purified using reversed phase chromatography – including ODS, C8, or C4 bonded phases.
For hydrophilic compounds or HILIC separations, consider our APS phase.

Bulk Silica Gels for Small Molecule Purification

The following DAISOGEL products are suitable for the purification of small molecules. Click on a pore size to learn more.

Recommended Pore Size (Å)
ODS Phase C8 Phase C4 Phase APS Phase
PK Series 100 100 100
P Series 100 120
200
HP Series 100 100
RPS Series 100
120
200
BP Series 120
200
BIO Series 120
200
120
200
120
200

Did you know?

DAISOGEL offers unbonded spherical silica gel for normal phase chromatography.