BULK SILICA

C4 Phases: SP-C4-BIO

As recombinant peptides, oligonucleotides, and proteins continue to be a driving force for new pharmaceuticals, DAISOGEL has launched the BIO Series of spherical silica gels.

C4-BIO Series is suitable for purification of small peptides, microbial proteins (insulin) and oligonucleotides that are too strongly retained on ODS or C8 phases. With its significant improvement in durability against acidic and alkalic resistance, C4-BIO Series can be used for an extended period in acidic mobile phase conditions and regenerated with solvents containing NaOH.

wide pH range C18 silica gel

Typical Applications

Wide pH range and pore size range for small, mid, and large molecules

Small Molecules

Synthetic Peptides

Ultra High Purity

The BIO Series silica gels are equipped with a narrow particle size distribution, ultra high purity totally spherical base silica gel, and high density bonding for performance under extreme pH conditions.

C4-BIO Series Selection Chart

Pore Size (Å)Molecular Weight Range (Da)Example Application
120Low (<2000)Small peptides
200Mid (2000-6000)Insulin
300High (>6000)Proteins

Available in 120, 200, and 300 Å pore sizes and 5 μm, 10 μm, 15 μm, and 20 μm particle sizes

Ordering Information (Bonded Phase C4)

Product NamePore Size (Å)Particle Size (µm)Pore Volume (mL/g)Surface Area (m2/g)% of Carbon
SP-120-5-C4-BIO120513009
SP-120-10-C4-BIO1201013009
SP-120-15-C4-BIO1201513009
SP-120-20-C4-BIO1202013009
SP-200-5-C4-BIO20051.12006
SP-200-10-C4-BIO200101.12006
SP-200-15-C4-BIO200151.12006
SP-200-20-C4-BIO200201.12006
SP-300-5-C4-BIO30050.91003
SP-300-10-C4-BIO300100.91003
SP-300-15-C4-BIO300150.91003
SP-300-20-C4-BIO300200.91003

Helpful Tip

C4-BIO Series is alkaline stable between pH 1.5 and 11. The 300 Å wide pore C4-BIO Series is ideal for bulky molecules and proteins.

Other DAISOGEL Products in BIO Series