Novel Pre-Screening Kit
Choosing the right stationary phase for your new purification process is a crucial decision, as it will not only have a significant impact on the process economics of the purification step, but it may very well drive the economic feasibility of your entire API manufacturing process.
Since it is impossible to predict which stationary phase will provide the best outcome for any given process, bench-scale trials are necessary to discover the right solution for your unique molecule.
Nowadays, the scientist’s stationary phase choices are too numerous! You may have dozens, or even hundreds, of “trial” or “scouting” columns available to compare. These comparison experiments are referred to as “column screening” by chromatographers. However, screening numerous columns is an inefficient practice that costs too much time and money.
Find your phase direction
Select your column size and use the DAISOGEL COMPASS kit to quickly determine the appropriate bonded phase for your separation.
Refer to our screening guide
Check our screening guide to direct you towards the appropriate DAISOGEL products to screen for your application based on the COMPASS results.
Compare various phases
Experimentally screen the chosen assortment of appropriate trial columns on your molecule.
Choose the best solution
Select the best stationary phase based on your screening experiment results.
What is the COMPASS?
The COMPASS is not a screening kit. It is a kit comprised of four columns that each have a unique stationary phase utilizing a different separation mechanism to be used prior to screening. With the COMPASS, you can quickly test your molecule on four phases to determine which direction you should take for an optimized screening.
Four Bonded Phases of the COMPASS
TIP: Hover your cursor over each phase for more info!
OCTADECYL BONDED PHASE
OCTYL BONDED PHASE
BUTYL-PHENYL BONDED PHASE
NON-ENDCAPPED BUTYL BONDED PHASE
*Particle size of the phases is 8 μm to provide the best separation insight while still informing preparative performance. If you require different column sizes, simply let us know and we can produce a custom COMPASS for you.
Configuration of a Standard COMPASS Kit
|Column Size (mm)||Particle Size (μm)||Phases Included|
|4.6 x 150||8||SP-100-8-ODS-P
|4.6 x 250||8||SP-100-8-ODS-P
Did you know?
The COMPASS is ideal for your process development of molecules that don’t have a solid starting point. This could be for a novel compound or molecule with a unique chemistry that you have not purified before.